Mechanisms of Cyclooxygenase-2 Inhibition and Cardiovascular Side Effects—The Plot Thickens: Fig. 1
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چکیده
منابع مشابه
Mechanisms of cyclooxygenase-2 inhibition and cardiovascular side effects: the plot thickens.
Cyclooxygenase (COX)-2 is a major player in inflammation and cancer. It is one of two COXs that convert arachidonic acid to a common intermediate in the production of prostaglandins and thromboxane. COX-2 is inhibited by nonselective COX inhibitors such as aspirin, ibuprofen, and sulindac as well as by the COX-2–selective inhibitors celecoxib and rofecoxib. Inflammation is an important contribu...
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The Promise Introduction of selective cyclooxygenase (COX)-2 inhibitors held a promise of improved treatment of arthritis without the gastrointestinal effects associated with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), which effect both COX-1 and COX-2 activity. Celecoxib, etodolac, meloxicam, and rofecoxib are classified as selective COX-2 inhibitors. Initial placebo and l...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2009
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-09-0033